ABSTRACT
The aim of this study was to conduct a literature review of impacts of protein malnutrition and/or early food deprivation on the formation of the growth plate in young animals. A search was performed using the databases PubMed/MEDLINE, LILACS, SciELO and the Cochrane Library, without language restrictions or any limit as to year. Initially, 150 articles were identified, however, after application of the inclusion and exclusion criteria only five remained. In three studies the nutritional stress was due to protein malnutrition, another due to fasting and the fifth was due to food restriction. All the studies had some methodological omissions. The studies included in this review-demonstrated corroboration in the results obtained, regardless of whether the animals had been subjected to protein malnutrition, fasting or food restriction. The findings uncovered were reduction in height of the epiphyseal plate, in the number of proliferative and hypertrophic chondrocytes, in the bone growth rate and in the longitudinal length of the bone in animals subjected to nutritional stress. In this systematic review, it was possible to observe the susceptibility of the epiphyseal plate in the first place, and secondarily, of the long bones to the effects of nutritional stress by means of protein malnutrition or food deprivation applied in young animals.
El objetivo fue realizar una revisión de la literatura sobre el impacto de la desnutrición proteica y/o privación de alimentos en la temprana formación de la placa de crecimiento en animales jóvenes. La búsqueda fue realizada en las bases de datos PubMed/MEDLINE, LILACS, SciELO y Biblioteca Cochrane sin restricción de lengua o límite de año. Fueron identificados inicialmente ciento cincuenta artículos que, posterior a la aplicación de los criterios de inclusión y exclusión, solo quedaron cinco. En tres estudios el estrés nutricional fue causado por la desnutrición proteica, otro al ayuno y el tercero fue por restricción alimentaria. Todos los estudios presentaban algunas omisiones metodológicas. Las investigaciones incluidas en esta revisión demostraron concordancia en sus resultados obtenidos, independientemente que los animales hayan sido sometidos a desnutrición proteica, ayuno o restricción alimentaria. Los datos obtenidos mostraron que los animales sometidos al estrés nutricional presentaron una reducción en la altura de la placa epifisaria, en el número de condrocitos proliferativos e hipertróficos, en la tasa de crecimiento óseo y en la longitud ósea. En esta revisión sistemática fue posible observar que los efectos del estrés nutricional, a través, de desnutrición proteica o de la privación alimentaria aplicada en animales jóvenes presentan, en primer lugar, una susceptibilidad de la placa epifisaria y de los huesos largos de manera secundaria.
Subject(s)
Animals , Bone Development , Food Deprivation , Growth PlateABSTRACT
Introdução: A dor é um fenômeno multidimensional que dificulta o desenvolvimento das atividades cotidianas. A aplicação de estimulação elétrica nervosa transcutânea (transcutaneous electrical nerve stimulation TENS) está entre uma das modalidades mais usadas para o tratamento da dor. Objetivo: O objetivo deste estudo foi verificar se a TENS acupuntural (baixa frequência) influencia a dor aguda produzida pela hipotermia local em indivíduos saudáveis, quando os eletrodos estão localizados nos acupontosTA5 e CS6 e na aplicação placebo. Métodos: Trinta e dois voluntários, de ambos os gêneros, foram alocados,aleatoriamente, nos grupos TENS e placebo. O estudo consistiu em três momentos: hipotermia sem eletroanalgesia, hipotermia com eletroanalgesia ou placebo, e hipotermia pós-eletroanalgesia ou placebo, para avaliar o efeito da TENS e do placebo na latência do limiar de dor e na intensidade da dor.Resultados: Os resultados mostraram que a latência do limiar de dor aumenta significativamente quando comparados os momentos antes e depois do uso da TENS, enquanto o grupo placebo não mostrou significância entre seus ciclos de experimentação. A intensidade da dor não sofreu influencia da TENS e do placebo. Conclusão: Nossos resultados sugerem que a TENS acupuntural aplicada sobre a área dos acupontos TA5 e CS6 é eficaz em aumentar a latência do limiar de dor, mas não interfere na intensidade da dor.
Introduction: Pain is a multidimensional phenomenon that hampers the development of daily activities. The application of transcutaneous electrical nerve stimulation (TENS) is among one of the most widely used to treat pain. Objective: The aim of this study was to determine whether acupunctural TENS (low frequency) influences the acute pain produced by local hypothermia in healthy subjects, when the electrodes are located on acupoints TA5 and CS6 and in placebo application. Methods:Thirty-two volunteers, both male and female, were randomly allocated to TENS groups and sham. The study consisted of three phases: hypothermia without TENS analgesia, hypothermia with TENS analgesia or placebo, and hypothermia post-TENS analgesia or placebo, to evaluate the effect of TENS and placebo in the latency of pain threshold and pain intensity. Results: The results show that the latency of pain threshold significantly increased when compared to the moments before and after use of TENS, while the placebo group showed no significant difference between its cycles of experimentation. Pain intensity was not affected by TENS and placebo. Conclusion: Our results suggest that TENS acupunctural applied over the area of acupoints TA5 and CS6 is effective in increasing the latency of pain threshold, but does not interfere in pain intensity.